diff --git a/src/xenia/gpu/vulkan/vulkan_command_processor.cc b/src/xenia/gpu/vulkan/vulkan_command_processor.cc
index 019fc3d6a..a6b479726 100644
--- a/src/xenia/gpu/vulkan/vulkan_command_processor.cc
+++ b/src/xenia/gpu/vulkan/vulkan_command_processor.cc
@@ -2440,6 +2440,9 @@ bool VulkanCommandProcessor::IssueDraw(xenos::PrimitiveType prim_type,
             descriptor_sets_kept,
             uint32_t(SpirvShaderTranslator::kDescriptorSetTexturesPixel));
       }
+      // Invalidate descriptor set bindings for incompatible sets.
+      current_graphics_descriptor_sets_bound_up_to_date_ &=
+          (UINT32_C(1) << descriptor_sets_kept) - 1;
     } else {
       // No or unknown pipeline layout previously bound - all bindings are in an
       // indeterminate state.